Martina Wild, Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Lucía Facal, Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Zara Martínez, Cátedra de Endocrinología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Mercedes Piñeyro, Cátedra de Endocrinología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Natalia Ibañez, Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
José Boggia, Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Gabriela Ottati, Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Lymphocytic hypophysitis is a rare condition that requires a high index of suspicion in patients with arginine vasopressin deficiency (AVP-D), especially in the presence of a systemic autoimmune disease. Currently, there are no non-invasive studies available for its diagnosis nor a clear treatment guideline to follow. We present a patient with a recent onset of systemic lupus erythematosus who was diagnosed with AVP-D, manifested by polyuria that began at the end of her last pregnancy and the most plausible diagnosis was lymphocytic hypophysitis. She demonstrated significant improvement with exogenous desmopressin and immunosuppressive treatment.
Keywords: Systemic lupus erythematosus. Arginine vasopressin deficiency. Central diabetes insipidus. Polyuria. Autoinmune hypophysitis. Lymphocytic hypophysitis.
