António Figueiredo, Serviço de Patologia Clínica, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Teresa Ferreira, Serviço de Pediatria, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Sónia Mota Faria, Serviço de Patologia Clínica, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Filipa Salazar, Serviço de Patologia Clínica, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Lucinda Silva, Serviço de Patologia Clínica, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Alexandra Santos, Serviço de Patologia Clínica, Hospital Prof. Doutor Fernando Fonseca E.P.E., Amadora, Portugal
Introduction: Leukoerythroblastosis is a rare condition characterized by leukocytosis and myeloid and erythroid precursors in the peripheral blood. Only a few cases of parvovirus B19 associated leukoerythroblastosis in a context of SCD have been reported. Case report: A 27-month-old girl with HbSS presented with fever and non-specific symptoms; a WBC of 92,300 × 109/L, hemoglobin 3.3 g/dL, platelets 607 × 109/L, and 113 NRBCs/100 WBCs; her reticulocyte count (RC) was 11,000/uL. A marked leukoerythroblastosis and thrombocytosis were evident on the blood smear. After appropriate treatment and within 48 hours her RC rose to 391,000/uL, her WBC had fallen to 19,500 and her platelets to 419,000. The PB19 IgM was positive. Discussion: This case describes the unusual association between leukoerythroblastosis and thrombocytosis, in conjunction with a transient aplastic crisis secondary to PB19 infection. It also illustrates the clinical utility of the IRF parameter in documenting marrow recovery. PB19 should be considered in the laboratory examinations of children with leukoerythroblastosis.
Keywords: Leukoerythroblastic. Thrombocytosis. Sickle cell disease. Parvovirus B19. Aplastic anemia.
