Germán A. Nolasco-Rosales, 1Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., Mexico
Juan D. Cruz-Castillo, Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., Mexico
Ester Rodríguez-Sánchez, Diabetes Clinic,, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa, Tab., Mexico
Karla I. Jiménez-López, Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., Mexico
José J. Martínez-Magaña, Department of Psychiatry, Yale University School of Medicine, New Haven, USA
Guillermo E. Villar-Juárez, Medicine School, Universidad Anáhuac Querétaro, Qro., Mexico
Yazmín Hernández-Díaz, Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tab., Mexico
Carlos A. Tovilla-Zárate, Comalcalco Multidisciplinary Academic Division, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tab., Mexico
Crystell G. Guzmán-Priego, Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., Mexico
Alejandro Marín-Medina, University Center for Health Sciences, Universidad de Guadalajara, Guadalajara, Jal., Mexico
Isela E. Juárez-Rojo, Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., Mexico
Background: It has recently been observed that the phenotype of patients with type 1 diabetes (T1D) is changing. Objective: To identify parameters that allow the recognition of metabolic syndrome (MS) and insulin resistance (IR) in adult patients with T1D. Methods: We formed four groups based on the presence of MS and IR: MS + IR + (n = 5), MS + IR – (n = 3), MS – IR + (n = 5), and MS – IR – (n = 6). The receiver operating curves (ROC) evaluated the sensitivity and specificity for MS and peripheral IR detection. Results: Eight patients (42.10%) had MS, and 10 (52.6%) had IR. We observed differences between the groups in the ratio of triglycerides to HDL cholesterol, levels of glycosylated hemoglobin, and HDL-c. A triglycerides/HDL ratio > 2.82, and glycosylated hemoglobin level > 8.7% correlated best with the presence of MS and IR, respectively. Conclusion: The triglycerides/HDL ratio could predict MS in adult patients with T1D. Furthermore, the eGDR could detect IR without clinical features of MS in patients with T1D.
Keywords: Type 1 diabetes. Metabolic syndrome. Insulin resistance. High-density lipoprotein cholesterol. Triglycerides. Glycated hemoglobin A.
