Anna P. Bazan-Rodríguez, Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
María F. Velasco-Delgado, Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Nora G. Sánchez-Lorenzo, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico
Alejandra Ruiz-Mafud, Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
José M. Ramírez-Becerril, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico
Xicotencatl Gutiérrez-Palomo, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo, Mexico
Amin Cervantes-Arriaga, Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Mayela Rodríguez-Violante, Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Objective: The objective of the study is to evaluate the association between nutritional status, clinical characteristics, and quality of life in patients with Parkinson’s disease (PD). Methods: This is an observational, analytical, cross-sectional study conducted at a reference center. Nutritional status was assessed using the Mini Nutritional Assessment-Shot Form (MNA-SF) and categorized as normal nutrition, at risk of malnutrition, or malnourished. Motor, non-motor symptoms, depression, cognition, motor complications, and quality of life were evaluated. Group differences were assessed using Kruskal–Wallis test, and exploratory multivariable linear regression models were fitted. Results: Ninety patients were included, with a mean age of 61.02 ± 12.32 years. Nutritional status was normal in 50.0%, at risk of malnutrition in 33.3%, and malnourished in 16.6%. Significant differences across nutritional groups were observed for the Movement Disorder Society-unified PD rating scale (MDS-UPDRS) Part III, MDS-UPDRS total, Hoehn-Yahr stage, Hamilton Depression score, PD questionnaire-8 index, MDS-Non-Motor Rating Scale total, and Eating Assessment Tool-10 (EAT-10). In adjusted models, nutritional status was not independently associated with motor severity, non-motor burden, or quality of life; however, malnutrition remained associated with higher Hamilton-D scores, and at-risk nutritional status remained associated with higher EAT-10 scores. Conclusions: Nutritional impairment in PD was associated with worse clinical profiles in unadjusted analyses, although most associations attenuated after adjustment. These findings support routine nutritional screening.
Keywords: Parkinsons disease. Nutritional status. Malnutrition. Motor symptoms. Non-motor symptoms.
