Carlos M. Restrepo, Facultad de Medicina, Universidad del Norte, Barranquilla, Colombia
Vanessa Villavicencio-Cerón, Departamento de Nefrología, Hospital IEES Portoviejo, Portoviejo, Ecuador
Rodrigo Daza-Arnedo, Comité de Riñón, Diabetes y Metabolismo, Asociación Colombiana de Nefrología e HTA, Bogotá, Colombia
Jorge Rico-Fontalvo, Comité de Riñón, Diabetes y Metabolismo, Asociación Colombiana de Nefrología e HTA, Bogotá, Colombia; Departamento de Nefrología, Universidad Simón Bolívar de Barranquilla, Barranquilla, Colombia
Marcelo De Rosa, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina
Verónica P. Remache-Otanez, Servicio de Anatomía Patológica, Hospital de Especialidades Eugenio Espejo, Quito, Ecuador
IgA nephropathy is the most common glomerulopathy, characterized by immune complex deposits in the glomeruli causing renal damage. It is associated with genetic predisposition and abnormal immune responses. We present the case of a 15-year-old adolescent with glomerular hematuria and acute renal deterioration following a viral illness and exposure toNSAIDs and iodinated contrast. Renal biopsy revealed IgA nephropathy and acute tubulointerstitial nephritis (ATIN) witheosinophilia. She received methylprednisolone pulses, achieving renal recovery. This case highlights the importance of distinguishing acute complications in patients with IgA nephropathy to ensure timely and appropriate management. IgA nephropathy and interstitial nephritis are connected through inflammatory mechanisms in the kidney. Although IgA nephropathyprimarily affects the glomeruli with different histologic patterns, in this case we found interstitial inflammation exacerbatingdamage and accelerating the deterioration of renal function. This highlights the importance of addressing all the mechanismof acute kidney injury to prevent progression to end-stage renal disease.
Keywords: IgA nephropathy. Tubulointerstitial nephritis. Renal biopsy. Hematuria.
